A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma.
A phase 1 clinical trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study carried out by the multicenter Children’s Oncology Group (COG). The results were “an exciting proof-of-principle” for the targeted treatment, said the study leader, Yaël P. Mossé, M.D., a pediatric oncologist at The Children’s Hospital of Philadelphia.
“We are entering a new era of cancer therapy, in which we use knowledge of basic biology to design very specific drugs that target cancer cells with potentially less side effects on healthy tissue,” said Mossé. “In addition, as we concentrate on targets in molecular pathways, we move away from an exclusive focus on one form of cancer to customizing treatments according to biological activity. Abnormal ALK activity occurs in subtypes of neuroblastoma and subtypes of lymphoma, so identifying ALK activity in individual patients may enable us to provide the most effective care.”
To view Multimedia News Release, go to http://www.multivu.com/mnr/50776-childrens-hospital-philadelphia-lymphoma-neuroblastoma-oncology-gene-trial
An Extra-Ordinary Beginning, the debut novel by A.D. Winch about a new kind of superhero, is out now. Children and adults around the world who are tired of the stereotypical superhero – white adult male with his underpants outside his trousers – will find this story is for them.
Ursula and Eric are characters readers can relate to and whose super powers are within their reach. Ursula is originally from Africa and promises to be the first significant superhero for girls regardless of colour, nationality or race. In a genre in which girls are seen as side-kicks or sub-plots, along comes a female character who is central to an entire series of books. This is not to say that the internationally educated Eric is irrelevant. There are more than three million students being educated worldwide who now have a hero who shares their experience and can truly be described as a global citizen.
To view Multimedia News Release, go to http://www.multivu.com/mnr/58648-AD-winch-novel-an-extra-ordinary-beginning
http://fitnessweightlosscenter.com - Standing Barbell Curls - Biceps Workout - A fantastic exercise for isolating the biceps muscles. Everyone wants to show off their guns and the standing barbell curl is a great way to pump up your biceps. As with all exercises to get the maximum results you need to perform the exercise correctly.
The single biggest mistake people make when performing the standing barbell curl is swinging the body back. This defeats the whole purpose of the exercise which is to isolate the biceps muscle. Your body should remain fixed and only the biceps muscles used to lift the weight. If you can't lift the weight without swinging your body back then you need to use less weight until you can effectively perform the exercise.
Another mistake people make is not keeping your elbows tucked into your sides. You should not let your elbows leave your side. Again, we are going for the isolation of the biceps and you do not want to use any other muscles or movements to lift the weight.
The third most common mistake when performing the standing barbell curl is to drop the weight too quickly. To maximize the effectiveness of the exercise you need to slowly lower the weight back to the starting position. If you can't lower the weight slowly you need to reduce the weight until you can. By isolating the biceps on the way up and on the way down you will get amazing results with the standing barbell curl.
For more info drop by our YouTube channel http://www.youtube.com/user/FitnessWeightLossCtr or visit us on the web at
http://fitnessweightlosscenter.com and find us on Facebook at http://facebook.com/fitnessweightlosscenter
24-hour preschool television channel Sprout is set to premiere its newest original series, The Chica Show (26 × 11’ episodes), on Saturday, November 24 at 11:30 a.m. ET, with encore presentations at 5:30 p.m. and 5:45 p.m. ET. Promoting social-emotional development in preschoolers through creative play, The Chica Show is a mix of live action and animation that follows the imaginative adventures of Chica and her cast of friends (including Stitches, an animated character voiced by Mario Lopez) as they explore all the whimsical, humorous costumes and accessories in the Costume Coop – a playful shop filled with every costume imaginable. Each episode takes the viewer on a journey into Chica’s imagination where problems are solved, questions are answered and adventure filled lands are explored.
To view Multimedia News Release, go to http://www.multivu.com/mnr/58781-sprout-new-original-series-the-chica-show-premiere
The beauty of spring is in full bloom at PANDORA with the release of new charms, rings, earrings and pendants inspired by the oriental beauty of cherry blossoms, enchanted fairy tales, growing gardens and budding romance.
Explore the ever-changing splendor of pink cherry blossoms set in sterling silver or 14k gold or tap into your romantic side with whimsical fairy tale charms depicting a faraway castle, frog prince, enchanted mouse, fairy tale book or caged song bird. As with all PANDORA pieces, each charm features a delicate and lovely level of detail such as a 14k gold crown placed on the frog prince or a 14k gold crown with a pink cubic zirconia on the bottom of the castle.
To view Multimedia News Release, go to http://www.multivu.com/mnr/59719-pandora-jewelry-spring-collection
In honor of National Potato Day, Aug. 19, and in celebration of having the #1 selling refrigerated mashed potatoes in America¹, Bob Evans Food Products is kicking off its newest campaign – Mad About Mashed – to thank their valued customers in a smashingly creative way.
The prime focus of the new campaign is a signature, gourmet recipe collection – the Mad About Mashtini Recipe Collection – made with Bob Evans signature refrigerated mashed potatoes and garnished with tantalizing ingredients like parmesan crisps, Boursin cheese and basil pesto. The collection, created by Bob Evans Culinary Team, gives entrée-appeal to a staple side dish, and includes six new recipes, including the Sweet Tater Twist Mashtini™, Classy Carbonara Mashtini™, Mad-iterranean Mashtini™, Fiesta-tini™, Clubhouse Mashtini™ and Smoky Spud BBQ Mashtini™.
To view Multimedia News Release, go to http://www.multivu.com/mnr/56866-bob-evans-national-potato-day-mad-about-mashed-campaign
Admittedly, there’s a risk in any course we follow other than this, but every lesson of history tells us that the greater risk lies in appeasement, and this is the specter our well-meaning liberal friends refuse to face—that their policy of accommodation is appeasement, and it gives no choice between peace and war, only between fight or surrender. If we continue to accommodate, continue to back and retreat, eventually we have to face the final demand—the ultimatum. And what then—when Nikita Khrushchev has told his people he knows what our answer will be? He has told them that we’re retreating under the pressure of the Cold War, and someday when the time comes to deliver the final ultimatum, our surrender will be voluntary, because by that time we will have been weakened from within spiritually, morally, and economically. He believes this because from our side he’s heard voices pleading for “peace at any price” or “better Red than dead,” or as one commentator put it, he’d rather “live on his knees than die on his feet.” And therein lies the road to war, because those voices don’t speak for the rest of us.
You and I know and do not believe that life is so dear and peace so sweet as to be purchased at the price of chains and slavery. If nothing in life is worth dying for, when did this begin—just in the face of this enemy? Or should Moses have told the children of Israel to live in slavery under the pharaohs? Should Christ have refused the cross? Should the patriots at Concord Bridge have thrown down their guns and refused to fire the shot heard ’round the world? The martyrs of history were not fools, and our honored dead who gave their lives to stop the advance of the Nazis didn’t die in vain. Where, then, is the road to peace? Well it’s a simple answer after all.
You and I have the courage to say to our enemies, “There is a price we will not pay.” “There is a point beyond which they must not advance.” Winston Churchill said, “The destiny of man is not measured by material computations. When great forces are on the move in the world, we learn we’re spirits—not animals.” And he said, “There’s something going on in time and space, and beyond time and space, which, whether we like it or not, spells duty.”
You and I have a rendezvous with destiny.
We’ll preserve for our children this, the last best hope of man on earth, or we’ll sentence them to take the last step into a thousand years of darkness.”
Ko Samet is a rather small Island where will find some of the most beautiful beaches in Thailand. The island is located in Rayong province, Southeast of Bangkok and Pattaya. The journey takes about 2.30 hours by car from Bangkok and aroud 30 min ferry ride from Baan Pae Pier.
The holidays offer much to look forward to, like spending time with friends and family sharing in the season of joy and generosity and creating memories to last a lifetime. This year, spend more time making holiday memories with loved ones by incorporating fresh, delicious, time-saving products like Simply Potatoes in your holiday meal planning.
To view Multimedia News Release, go to http://www.multivu.com/mnr/57422-simply-potatoes-simply-fy-holiday-mealtime
The new single from Puglisi, Blow Along! Music Production by: Mirk Music. Produced by: Scriptonite. Filmed and edited by: Zueslytning Multimedia Production (http://www.youtube.com/user/Zueslytning) http://www.youtube.com/watch?v=9DbuOgOhMUs Look out for the NEW album, The Bright Side of a Nightmare, dropping LATE JANUARY! Facebook: https://www.facebook.com/FlightTeamManagement Website: http://flightteamtunes.com/ Twitter: https://twitter.com/ThePuglisi Instagram: http://instagram.com/thepuglisi Thank you to everyone who came out and helped with the video! I couldn't have done it without you!!!!
Eight out of 10 people will be affected by back pain at some point during their lives, making it the No. 1 cause of disability worldwide and resulting in as much as $200 billion in lost wages and productivity. Many sufferers struggle for years to find relief, but treatment options often only provide short-term relief or, in the case of pain medication, carry serious side effects, including drowsiness, liver damage and potential for addiction. Now, thanks to Hocoma, a leader in the development of robotic and sensor-based medical devices for functional movement therapy, consumers have a new way to improve and sustain low back health in the comfort of their own home.
To view the Multimedia News Release, go to http://www.multivu.com/players/English/7370551-hocoma-innovative-medical-device-therapeutic-gaming-technology-valedo-low-back-health/
While browsing in a rare book store in Arkham, Sean finds an occult book with an ad seeking an apprentice sorcerer, from a newspaper dated March 21, 1895. Even more intriguing, the ad specifically requests applicants reply by email.
Sean’s always been interested in magic, particularly the Lovecraftian dark mythology. The advertiser, Reverend Redemption Orne, claims to be a master of the occult born more than 300 years ago. To prove his legitimacy, Orne gives Sean instructions to summon a harmless but useful familiar—but Sean’s ceremony takes a dark turn, and he instead accidentally beckons a bloodthirsty servant to the Cthulhu Mythos god Nyarlathotep. Now Sean must find and bind the servitor, before it grows too strong to contain. But strange things are already happening in the town of Arkham. Welcome to the darker side of New England in the first of a new series from Anne Pillsworth. Find out more at http://us.macmillan.com/books/9780765335890 YA/Fantasy
