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Researchers have discovered that a subtype of leukemia characterized by a poor prognosis is fueled by mutations in pathways distinctly different from a seemingly similar leukemia associated with a much better outcome. The findings from the St. Jude Children’s Research Hospital — Washington University Pediatric Cancer Genome Project (PCGP) highlight a possible new strategy for treating patients with this more aggressive cancer.
The work provides the first details of the genetic alterations fueling a subtype of acute lymphoblastic leukemia (ALL) known as early T-cell precursor ALL (ETP-ALL). The results suggest ETP-ALL has more in common with acute myeloid leukemia (AML) than with other subtypes of ALL. The study appears in the January 12 edition of the journal Nature.
To view Multimedia News Release, go to http://www.multivu.com/mnr/46768-st-jude-cancer-genome-sequencing-project-combat-aggressive-leukemia
New findings from the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project (PCGP) have helped identify the mechanism that makes the childhood eye tumor retinoblastoma so aggressive. The discovery explains why the tumor develops so rapidly while other cancers can take years or even decades to form.
The finding also led investigators to a new treatment target and possible therapy for the rare childhood tumor of the retina, the light-sensing tissue at the back of the eye. The study appears in the January 11 advance online edition of the scientific journal Nature.
To view Multimedia News Release, go to http://www.multivu.com/mnr/46767-st-jude-genome-project-treatment-childhood-eye-tumor-retinoblastoma
Researchers have identified the first gene mutation associated with a chronic and often fatal form of neuroblastoma that typically strikes adolescents and young adults. The finding provides the first clue about the genetic basis of the long-recognized but poorly understood link between treatment outcome and age at diagnosis.
The study involved 104 infants, children and young adults with advanced neuroblastoma, a cancer of the sympathetic nervous system. Investigators discovered the ATRX gene was mutated only in patients age 5 and older. The alterations occurred most often in patients age 12 and older. These older patients were also more likely than their younger counterparts to have a chronic form of neuroblastoma and die years after their disease is diagnosed.
To view Multimedia News Release, go to http://www.multivu.com/mnr/52992-st-jude-pediatric-cancer-genome-project-neuroblastoma-research
The St. Patrick’s Festival is one of the highlights of Ireland’s cultural calendar — a week-long celebration of music, dance, outdoor spectaculars and of course, on March 17th, the stunning St. Patrick’s Day parade through the historic streets of Dublin. The festival is the traditional starting point of the holiday season and what a year 2012 is going to be.
2012 is the year when Northern Ireland will take center stage with a series of spectacular occasions. Titanic Belfast, the largest Titanic visitor experience in the world, will open its doors in April. The new visitors centre at the UNESCO world heritage site at the Giant’s Causeway will open in the fall and the European Tour’s Irish Open golf tournament will return to Royal Portrush in June. These events and many more come under the banner ‘Northern Ireland 2012 –Your time, our place.’
To view Multimedia News Release, go to http://www.multivu.com/mnr/55131-tourism-ireland-st-patrick-s-day-dublin-the-gathering-welcome-vacation
Join Michael Flatley, Martin Sheen and Saoirse Ronan in answering Ireland’s call to use your connections this St. Patrick’s Day. The Irish ambassadors appear in an inspirational video on ConnectIreland.com calling on some 70 million people worldwide who claim Irish ancestry to use their connections to help create new jobs in Ireland.
Irish-American Lord of Dance Michael Flatley, whose parents emigrated from Ireland in 1947 to Chicago, has lent his support to ConnectIreland to deliver a new Irish Government programme called Succeed in Ireland to help promote Ireland as a destination for international business.
To view Multimedia News Release, go to http://www.multivu.com/mnr/53786-connectireland
Six Flags St. Louis debuted the new Bonzai Pipeline water slide today with the help of four couples who took the Xtreme plunge by riding the park’s first looping body slide to feature dual launching capsules, while exchanging their wedding vows. The Bonzai Pipeline water slide is located in Hurricane Harbor, Missouri’s only free water park with theme park admission.
The four couples who took their wedding vows were winners of a local contest. Each couple exchanged vows at the top of the structure and was pronounced husband and wife as they splashed down at the end of the slide.
To view Multimedia News Release, go to http://www.multivu.com/mnr/56372-six-flags-st-louis-new-ride-bonzai-pipeline-water-slide
To speed progress against cancer and other diseases, the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project today announced the largest-ever release of comprehensive human cancer genome data for free access by the global scientific community. The amount of information released more than doubles the volume of high-coverage, whole genome data currently available from all human genome sources combined. This information is valuable not just to cancer researchers, but also to scientists studying almost any disease.
To view Multimedia News Release, go to http://www.multivu.com/mnr/52993-st-jude-childrens-research-hospital-comprehensive-human-cancer-genome-data
Three presidents, two prime ministers and dozens of senior ministerial officials, over 75 Fortune 1000 top executives, and over 400 Russia’s leading business and finance figures were among the 5,000 all gathered at the Sixteenth St. Petersburg International Economic Forum from June 21–23 to discuss, debate and network what it takes to have “Leadership that Works.”
To view Multimedia News Release, go to http://multivu.prnewswire.com/mnr/prne/st-petersburg-international-economic-forum/56565/
While potatoes were introduced to Ireland in the late 16th century, cattle have been in the Emerald Isle since 3,500 BC. And corned beef and cabbage, so beloved in the U.S. for St. Patrick’s Day, is believed to be an American invention.
Dairying enjoys a proud history in Ireland, where there is no industrial farming. Cows still roam free on small family farms and graze in lush Irish pastures. From this extraordinary grass-fed diet comes milk so rich in beta-carotene, it turns butter and cheeses a natural gold.
To view the Multimedia News Release, go to http://www.multivu.com/mnr/65577-irish-dairy-board-kerrygold-st-patrick-s-day-irish-butter-and-cheese
The St. Baldrick’s Foundation, a volunteer-powered charity dedicated to funding childhood cancer research, announces its Kids Are Special: Let’s Treat Them That Way national campaign. Focused on celebrating kids and giving them the happy childhoods they deserve, the campaign highlights the need for finding treatments that are specifically designed for kids with cancer.
With this bold new initiative, St. Baldrick’s looks to change the narrative around pediatric cancers, by showing kids as their truest selves – fun-loving, carefree, refreshingly honest, and always a little goofy. St. Baldrick’s puts the emphasis back on kids, while disempowering the label of “cancer.” All communication is strategically designed to remind us all that as adults we have the power to give kids happy childhoods free from cancer by helping to fund the best research worldwide. The campaign includes TV, print, radio, digital, and billboard placements featuring real kids doing kid-like things; from playing with their food to getting caught with paint on their faces, all with the message: Kids Are Special: Let’s Treat Them That Way.
To view the multimedia release go to:
http://www.multivu.com/players/English/7610752-st-baldricks-kids-are-special/
The most detailed analysis yet of the role germline mutations in genes associated with cancer predisposition play in the development of childhood cancer suggests that comprehensive genomic screening may be warranted on all pediatric cancer patients, not just those with a family history of cancer. The study from the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project appears in the November 19 edition of the New England Journal of Medicine.
Ultimately, researchers anticipate that systematic monitoring of patients and family members who have germline mutations in cancer predisposition genes will allow the detection of cancers at their earliest and most curable stage, thereby improving the outcomes for these children and family members.
To view the multimedia release go to:
http://www.multivu.com/players/English/7692851-st-jude-hospital-genome-project/
