Researchers studying the genetic roots of the most common malignant childhood brain tumor have discovered missteps in three of the four subtypes of the cancer that involve genes already targeted for drug development.
A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma.
A phase 1 clinical trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study carried out by the multicenter Children’s Oncology Group (COG). The results were “an exciting proof-of-principle” for the targeted treatment, said the study leader, Yaël P. Mossé, M.D., a pediatric oncologist at The Children’s Hospital of Philadelphia.
“We are entering a new era of cancer therapy, in which we use knowledge of basic biology to design very specific drugs that target cancer cells with potentially less side effects on healthy tissue,” said Mossé. “In addition, as we concentrate on targets in molecular pathways, we move away from an exclusive focus on one form of cancer to customizing treatments according to biological activity. Abnormal ALK activity occurs in subtypes of neuroblastoma and subtypes of lymphoma, so identifying ALK activity in individual patients may enable us to provide the most effective care.”
To view Multimedia News Release, go to http://www.multivu.com/mnr/50776-childrens-hospital-philadelphia-lymphoma-neuroblastoma-oncology-gene-trial
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In an announcement made today, Lexmark International, Inc. (NYSE: LXK) introduced two new color laser multifunction products (MFPs) powered with intelligent, productivity-enhancing solutions to streamline paper-intensive business processes. Targeted to the rapidly growing mid-size workgroup segment, these intuitive MFPs exhibit a wide array of features and functions, adding to Lexmark’s impressive portfolio of leading-edge hardware and innovative software and solutions.
To view Multimedia News Release, go to http://multivu.prnewswire.com/mnr/lexmark/48232/
Bluefin Labs (www.bluefinlabs.com) unveiled technology today to discover and analyze what people say via social media about the shows and ads they watch on television in real time. The technology, currently in pilot with several global brands, agencies and media companies, lets marketers see audience response to mass media, providing insight to develop measurably more targeted and responsive campaigns.
To view Multimedia News Release, go to http://multivu.prnewswire.com/mnr/bluefinlabs/48357/
